INsTRuCT Publications


ESR1 - Zotta-A, Zaslona-Z, O'Neill-L.
Is citrate a critical signal in immunity and inflammation?
Journal of Cellular Signaling 2020, 1, 87-96.
https://doi.org/10.33696/Signaling.1.017


ESR1 - Zotta-A, [...], Zaslona-Z, O'Neill-L.
4-Octyl-Itaconate and Dimethyl Fumarate Inhibit COX2 Expression and Prostaglandin Production in Macrophages.
J. Immunol. 2021.
https://doi.org/10.4049/jimmunol.2100488


ESR1 - Zotta-A, [...], O'Neill-L.
Mitochondrial respiratory complex III sustains IL-10 production in activated macrophages and promotes tumor-mediated immune evasion.
Science Advances in revision.

ESR1 - Zotta-A, O'Neill-L., Yin-M.
Unlocking potential: the role of the electron transport chain in immunometabolism.
Trends in Immunology, 2024.
https://doi.org/10.1016/j.it.2024.02.002


ESR1 - Escher Toller-Kawahisa J, [...], Zotta-A, [...], O'Neill-L.
The metabolic function of pyruvate kinase M2 regulates reactive oxygen species production and microbial killing by neutrophils.
Nature Communications, 2023.
https://www.nature.com/articles/s41467-023-40021-6


ESR1 - Tristram A. J. Ryan, [...], Zotta-A, [...]
Dimethyl Fumarate and 4-Octyl itaconate are anticoagulants that suppress tissue factor in macrophages via inhibition of type I interferon.
Nature Communications, 2023.
https://doi.org/10.1038/s41467-023-39174-1


ESR1 - Zotta-A, [...]
Inflammasome Biology Pages 625-644
https://doi.org/10.1016/C2021-0-01161-5 (Books/Monographs)


ESR2 - Georg P, […], Kostevc T, […], Sawitzki B.
Complement activation induces excessive T cell cytotoxicity in severe COVID-19.
Cell 2021.
doi: 10.1016/j.cell.2021.12.040


ESR2 - Gressier E, […], Kostevc T, […], Bedoui S.
CD4+ T cell calibration of antigen-presenting cells optimizes antiviral CD8+ T cell immunity.
Nature Immunology 2023.
https://doi.org/10.1038/s41590-023-01517-x


ESR2 - Georg P, […], Kostevc T, […], Sawitzki B.
Complement activation induces excessive T cell cytotoxicity in severe COVID-19.
Cell 2022.
doi: 10.1016/j.cell.2021.12.040.


ESR3 - Fortunato-M, Morali-K, Passeri-L, Gregori-S.
Regulatory cell therapy in organ transplantation: achievements and open questions.
Frontiers in Immunology 23 February 2021.
https://doi.org/10.3389/fimmu.2021.641596


ESR3 - Morali-K, [...], Gregori-S.
IL-10-producing tolerogenic dendritic cells modulate antigen-specific B cell responses via T cells.
Manuscript submitted.

ESR3 - Morali-K, [...], Gregori-S.
Leveraging current insights on IL-10-producing dendritic cells for developing effective immunotherapeutic approaches.
FEBS Letters. 2024. Manuscript in revision.

ESR4 - Gonzalez-Perez M., Tarjuelo-Sanchez R., Shor Boris, Nistal-Villan E, Ochando J.
The BCG Vaccine for COVID-19: First Verdict and Future Directions.
Frontiers in Immunology 2021.
https://doi.org/10.3389/fimmu.2021.632478


ESR4 - Lozano-Ojalvo D, […], Gonzalez-Perez M., et al.
Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity in naive and COVID-19 recovered individuals.
Cell reports 2021.
https://doi.org/10.1016/j.celrep.2021.109570


ESR4 - Borobia A, […], Gonzalez-Perez M. et al.
Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-S-primed participants (CombiVacS): a multicentre, open-label, randomised, controlled, phase 2 trial .
The Lancet 2022.
https://doi.org/10.1016/S0140-6736(21)01420-3


ESR4 - Gonzalez-Perez M., [...], Ochando J.
Development of Potent Cellular and Humoral Immune Responses in Long-Term Hemodialysis Patients After 1273-mRNA SARS-CoV-2 Vaccination.
Frontiers in Immunology, 2022.
https://doi.org/10.3390/ph16040574


ESR4 - Gonzalez-Perez M., [...], Ochando J.
Maintenance of Potent Cellular and Humoral Immune Responses in Long-Term Hemodialysis Patients after 1273-mRNA SARS-CoV-2 Vaccination.
Pharmaceuticals (Basel), 2023.
https://doi.org/10.3389/fimmu.2022.845882


ESR4 - Schwarz M, [...], Gonzalez-Perez M., [...], Ochando J.
Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR.
Nature Biotechnology, 2022.
https://doi.org/10.1038/s41587-022-01347-6


ESR4 - García-Pérez J, [...], Gonzalez-Perez M., [...], Pérez-Olmeda M.
Immunogenic dynamics and SARS-CoV-2 variant neutralisation of the heterologous ChAdOx1-S/BNT162b2 vaccination: Secondary analysis of the randomised CombiVacS study.
EClinicalMedicine, 2022.
https://doi.org/10.1016/j.eclinm.2022.101529


ESR5 - Sahar A, [...], Lord P.
Tolerogenic dendritic cell reporting: Has a minimum information model made a difference?
PeerJ, 2023.
https://doi.org/10.7717/peerj.15352


ESR6 - Maaike Suuring and Aurélie Moreau.
Regulatory Macrophages and Tolerogenic Dendritic Cells in Myeloid Regulatory Cell-Based Therapies.
International journal of molecular science 2021.
https://doi.org/10.3390/ijms22157970


ESR6 - Suuring M, Amodio G, Rouel M, Raux A, Royer AL, Croyal M, Delhaye T, Santoni di Sio F, Gregori S, Moreau A.
Comparative Analysis of Transcriptional and Metabolic Profiles in ATDC and DC10.
Manuscript in preparation.


ESR6 - Suuring M, Rouel M, Dumont A, Maye A, Tilly G, Croyal M, Pecqueur C, Xavier P, Degauque N, Moreau A.
Regulation of CD8+ T Cell-Mediated Kidney Transplant Rejection by Human Tolerogenic Dendritic Cells.
Manuscript in preparation.


ESR10 - Verstegen NJM, […], Kreher C, [...].
Immune dynamics in SARS-CoV-2 experienced immunosuppressed rheumatoid arthritis or multiple sclerosis patients vaccinated with mRNA-1273.
eLife 2022
https://elifesciences.org/articles/77969


ESR13 - Morante Palacios-O, Fondelli-F, Ballestar-E, Martínez Cáceres-EM.
Tolerogenic Dendritic Cells in Autoimmunity and Inflammatory Diseases.
Trends Immunol. 2021.
https://doi.org/10.1016/j.it.2020.11.001


ESR13 - M. J. Mansilla, S. Presas-Rodríguez, A. Teniente-Serra, I. González-Larreategui, B. Quirant-Sánchez, F. Fondelli, N. Djedovic, D. Iwaszkiewicz-Grześ, K. Chwojnicki, Đ. Miljković, P. Trzonkowski, C. Ramo-Tello & E. M. Martínez-Cáceres.
Paving the way towards an effective treatment for multiple sclerosis: advances in cell therapy.
Cellular & Molecular Immunology 2021 18, 1353-1374.
https://doi.org/10.1038/s41423-020-00618-z


ESR13 - María José Mansilla, […], Fondelli F., […], Martinez Càceres E.
Transfection of Vitamin D3-Induced Tolerogenic Dendritic Cells for the Silencing of Potential Tolerogenic Genes. Identification of CSF1R-CSF1 Signaling as a Glycolytic Regulator.
Int. J. Mol. Sci. 2021.
https://doi.org/10.3390/ijms22147363


ESR13 - Quirant-Sánchez B., […], Fondelli F., […], Martinez Càceres E.
TCombined Therapy of Vitamin D3-Tolerogenic Dendritic Cells and Interferon-β in a Preclinical Model of Multiple Sclerosis.
Biomedicines 2021.
https://doi.org/10.3390/biomedicines9121758


ESR13 - Fondelli F., […], Martinez Càceres EM.
Toward 2nd generation cell immunotherapies for multiple sclerosis: Combining antigen specific approaches with immunomodulation.
Journal of Clinical Investigation,
manuscript in revision.


ESR14 - Hutchinson-JA, […], Cordero-L et al.
Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis.
Nature Communications 2021.
https://doi.org/10.1038/s41467-021-21572-y


ESR14 - Hannah-Lou Schilling, […], Cordero-L et al.
Development of a Flow Cytometry Assay to Predict Immune Checkpoint Blockade-Related Complications.
Frontiers of Immunology 2021.
https://doi.org/10.3389/fimmu.2021.765644


ESR14 - Glehr G., […], Cordero-L, [...]
External validation of biomarkers for immune-related adverse events after immune checkpoint inhibition.
Frontiers in Immunology 2022.
https://doi.org/10.3389/fimmu.2022.1011040


ESR14 - Cordero-L, [...], Riquelme P.
Human regulatory macrophages induce allogeneic regulatory T cells through Activin E.
Manuscript in preparation.


ESR15 - Cooke F, Nicorescu I.
Fluorine labelling of therapeutic human tolerogenic dendritic cells for 19F-magnetic resonance imaging.
Frontiers in Immunology 2022.
https://www.frontiersin.org/articles/10.3389/fimmu.2022.988667/full


ESR15 - Hunter B, Nicorescu I.
OPTIMAL: An OPTimised Imaging Mass cytometry AnaLysis framework for benchmarking segmentation and data exploration.
Cytometry: Part A 2024.
https://pubmed.ncbi.nlm.nih.gov/37750225/


ESR16 - Peter A, Berneman ZN, Cools N.
Cellular respiration in dendritic cells: Exploring oxygen-dependent pathways for potential therapeutic interventions.
Manuscript in preparation.


ESR16 - Peter A, Traitteur T, Tekavec S, […], Cools N.
The role of oxyen in metabolic programming of tolerogenic dendritic cells: Tailoring in vitro generation and immune-modulatory function.
Manuscript in preparation.


ESR18 - Ebbinghaus M, Wittich K, Bancher B, Lebedeva V, Appelshoffer A, Femel J, Helm MS, Kollet J, Hardt O, Pfeifer R.
Endogenous Signaling Molecule Activating (ESMA) CARs: A Novel CAR Design Showing a Favorable Risk to Potency Ratio for the Treatment of Triple Negative Breast Cancer.
Int J Mol Sci. 2024
https://doi.org/10.3390/ijms25010615



An important work resulting from “The ONE Study” project and INsTRuCT partners' previous collaboration
The Lancet: Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials
Prof Birgit Sawitzki et al.
Free download of the article: https://authors.elsevier.com/c/1b68ZV-4XAjTj